There is a debate about whether or not to use anti-seize when installing spark plugs. The official position of Autolite on this question is to consult the service manual for the vehicle being repaired and use anti-seize only where the original manufacturer recommends it.
The nickel coating on most modern spark plugs provides added protection from seizing in aluminum cylinder heads and has made anti-seize less important in spark plug installations. Anti-seize can alter the tightening torque up to 20%, increasing the risk of breakage. It can also create heat transfer and electrical conductivity concerns.
This video is sponsored by Autolite.